coenzyme Q10

Also indexed as

CoQ10, Ubiquinone
See also

Coenzyme Q10 for Sports & Fitness
Introduction

Coenzyme Q10 (CoQ10) is also called ubiquinone, a name that signifies its ubiquitous (widespread) distribution in the human body. CoQ10 is used by the body to transform food into adenosine triphosphate (ATP), the energy on which the body runs.
Where is it found?
CoQ10 is found primarily in fish and meat, but the amounts in food are far less than what can be obtained from supplements.
Coenzyme Q10 has been used in connection with the following conditions (refer to the individual health concern for complete information):
Science Ratings - Health Concerns
*** - Angina
*** - Heart attack
*** - High blood pressure
** - Cardiomyopathy
** - Cerebellar ataxia (familial)
** - Congestive heart failure
** - Gingivitis (periodontal disease)
** - Halitosis (if gum disease)
** - Macular degeneration (in combination with acetyl-L-carnitine and fish oil)
** - Migraine headaches
** - Parkinson’s disease
** - Renal (kidney) failure
** - Type 2 diabetes
* - Alzheimer’s disease
* - Athletic performance
* - Breast cancer
* - Chronic obstructive pulmonary disease (COPD)
* - HIV support
* - Infertility (male)
* - Insulin resistance syndrome (Syndrome X)
* - Lung cancer
* - Muscular dystrophy
* - Prostate cancer
* - Type 1 diabetes
*** - Reliable and relatively consistent scientific data showing a substantial health benefit.

** - Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

* - For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.
Who is likely to be deficient?
Deficiency is poorly understood, but it may be caused by synthesis problems in the body rather than an insufficiency in the diet. Low blood levels have been reported in people with heart failure, cardiomyopathy, gingivitis (inflammation of the gums), morbid obesity, hypertension, muscular dystrophy, diabetes, AIDS, and in some people on kidney dialysis. People with phenylketonuria (PKU) may be deficient in CoQ10 because of dietary restrictions.1 CoQ10 levels are also generally lower in older people. The test used to assess CoQ10 status is not routinely available from medical laboratories.
Which form of coenzyme Q10 is best?
Some,2 but not all,3 research suggests that a fat-soluble form of CoQ10 is absorbed better than CoQ10 in granular (powder) form.4
How much is usually taken?
Adult levels of supplementation are usually 30–90 mg per day, although people with specific health conditions may supplement with higher levels (with the involvement of a physician). Most of the research on heart conditions has used 90–150 mg of CoQ10 per day. People with cancer who consider taking much higher amounts should discuss this issue with a doctor before supplementing. There are several anecdotal reports of large amounts of CoQ10 resulting in improvements in certain types of cancer. However, controlled trials are needed to confirm these preliminary observations. Most doctors recommend that CoQ10 be taken with meals to improve absorption.
Are there any side effects or interactions?
Congestive heart failure patients who are taking CoQ10 should not discontinue taking CoQ10 supplements unless under the supervision of a doctor.
An isolated test tube study reported that the anticancer effect of a certain cholesterol-lowering drug was blocked by addition of CoQ10.5 So far, experts in the field have put little stock in this report because its results have not yet been confirmed in animal, human, or even other test tube studies. The drug used in the test tube is not used to treat cancer, and preliminary information regarding the use of high amounts of CoQ10 in humans suggests the possibility of anticancer activity.6 7 8
Drug Interactions
Certain medicines interact with coenzyme Q10: Some interactions may increase the need for coenzyme Q10 (+), other interactions may be negative (-) and indicate coenzyme Q10 should not be taken without first speaking with your physician or pharmacist, others may require further explanation (?). Refer to the individual drug article for specific details about an interaction.
Note: The following list only includes the generic or class name of a medicine. To find a specific brand name, use the Medicines index.
Atorvastatin (+)
Doxorubicin (+)
Fluvastatin (+)
Gemfibrozil (+)
Lovastatin (+)
Perphenazine (+)
Pravastatin (+)
Propranolol (+)
Simvastatin (+)
Thioridazine (+)
Timolol (+)
Tricyclic Antidepressants (+)
Warfarin (-)

Source: www.cncahealth.com